Manuel I may refer to:
*
Manuel I Komnenos
Manuel I Komnenos ( el, Μανουήλ Κομνηνός, translit=Manouíl Komnenos, translit-std=ISO; 28 November 1118 – 24 September 1180), Romanization of Greek, Latinized Comnenus, also called Porphyrogennetos (; "born in the purple"), w ...
, Byzantine emperor (1143–1180)
*
Manuel I of Trebizond
Manuel I Megas Komnenos ( el, Μανουήλ Κομνηνός; died March 1263) was Emperor of Trebizond from 1238 until his death. He was the son of Emperor Alexios I and his wife, Theodora. At the time Manuel reigned, the Empire of Trebizond co ...
, Emperor of Trebizond (1228–1263)
*
Manuel I of Portugal
Manuel I (; 31 May 146913 December 1521), known as the Fortunate ( pt, O Venturoso), was King of Portugal from 1495 to 1521. A member of the House of Aviz, Manuel was Duke of Beja and Viseu prior to succeeding his cousin, John II of Portugal, a ...
, King of Portugal (1496–1521)
*
Manuel I, Patriarch of Lisbon (1800–1869)
{{hndis, Manuel 01